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USP22 deubiquitinates Histone_H2B. 27 / 27
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"In addition, reduced expression of USP22 is associated with chromosomal instability (CIN), since efficient chromosome compaction during mitosis requires USP22 deubiquitination of H2B in metaphase (Jeusset et al., 2021)."
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"Interestingly, USP22 alone deubiquitinates very inefficiently histone H2B, and its activation requires association with TFTC/STAGA."
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"USP22 might de-ubiquitinate H2A and H2B, subunits of the human SAGA complex that are intimately linked to the transcriptional activation of the MYC gene and increased cell proliferation in HCC [XREF_BIBR]."
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"Apart from deubiquitinating histones H2A and H2B, USP22 also modulates transcription through stabilization of the p53-antagonizing deacetylase sirtuin-1 (SIRT1) to suppress p53-controlled transcription and to abrogate pre-mature senescence in pluripotent progenitor cells during embryonic development [5]."
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"As we discussed previously, USP22 is a component of a transcriptional activator complex SAGA and can deubiquitinate histones H2A and H2B, as well as several other substrates (Zhang et al., 2008a, b)."
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"Our observations regarding differentiation could not be correlated to H2B and H2Bub1 levels suggesting that H2B is only partially deubiquitinated by Usp22."
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"USP22 deubiquitylates both, H2A and H2B."
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"In yeast, the USP22 ortholog deubiquitylates H2B, resulting in Pol II Ser2 phosphorylation and subsequent transcriptional elongation."
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"USP22 is able to deubiquitinate histone H2A and H2B in vitro and is required for androgen receptor transcription activation."
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"However, while USP22 is capable of deubiquitinating H2B in vitro [36,53,60] and USP22 knockdown increases H2Bub1 levels on the IRF1 gene [18] , none of the published reports demonstrated a significant[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"One of the 21 subunits of SAGA is the DUB Ubp8 (USP22 in human) that deubiquitinates mUb histone H2B [ 28–30 ]."
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"USP22 was initially reported to promote deubiquitylation of histones H2A and H2B, leading to transcription activation."
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"USP22 forms part of the SAGA complex and requires the participation of cofactors like ATXN7L3 and ENY2 to deubiquitinate H2B, while USP27X functions independently of SAGA but also needs ATXN7L3 and ENY2 to act on H2B [8]."
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"The Suga and Wolberger reported cyclic peptide inhibitors of USP22 prevent histone H2B deubiquitination as a strategy for cancer drug development."
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"[2] Increased USP22 edits the histone code as part of the mammalian SAGA (Spt-Ada-Gcn5) complex by deubiquitinating H2A and H2B."
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"However, de-ubiquitylation of H2B by Usp22, the human homolog of yeast Ubp8, inhibits heterochromatic silencing and promotes gene activation [XREF_BIBR, XREF_BIBR]."
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"The requirement of ATXN7L3 for H2B deubiquitination by USP22, USP27x, and USP51 suggests that all three use the ATXN7L3 zinc finger to dock the H2A and H2B acidic patch in a manner similar to that shown in the structure of the yeast DUB module bound to ubiquitinated nucleosomes."
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"Consistent with H2B monoubiquitylation acting in a tumor suppressor pathway, overexpression of the deubiquitinase ubiquitin‐specific peptidase 22 (USP22, which eliminates H2B monoubiquitylation) also significantly promoted tumor growth (Fig. 7B)."
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"USP22 is a component of the SAGA transcriptional coactivator complex and can deubiquitinate H2A and H2B [XREF_BIBR - XREF_BIBR]."
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"USP22 may deubiquitinate H2A and H2B, subunits of the hSAGA complex that activate transcription factors and promote carcinogenesis [XREF_BIBR]."
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"USP22 induces changes in gene promoter regions by deubiquitinating histones H2A and H2B, thereby controlling transcription."
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"Previous studies have demonstrated that USP22 deubiquitinates histones H2A and H2B and regulates cell growth, cell-cycle regulation and signal transduction (4,5,17)."
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"Remarkably, USP22, the human ortholog of Ubp8, forms a similar SAGA DUB module and deubiquitinates both H2A and H2B."
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"USP22 can deubiquitinate histone H2B and is required for the activation of target gene transcription by Myc [11] ."
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"USP22 is one subunit of SAGA (Spt-Ada-Gcn5-acetyltransferase), and is involved in the deubiquitination of histones H2A and H2B and the acetylation of histone H4 in order to regulate the transcription and expression of numerous genes (15,16)."
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"As a subunit of hSAGA, USP22 participates in the deubiquitination of histones H2A and H2B and the acetylation of histone H4 to regulate gene transcription and expression."
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"For instance, USP22 can deubiquitinate histone H2B, thereby activating the transcription of Myc-target genes [126] ."
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