IndraLab

Statements

OTUD3 binds NFE2L2. 7 / 7
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"The interaction of NRF2 and OTUD3 was further confirmed by Co-IP, and it was shown that NRF2 could form a complex with OTUD3, which was abolished by the knockdown of BUB1b (Fig. 5D)."
39043653
reach
"Thus, the interaction of OTUD3 and NRF2 was BUB1b dependent."
39043653
reach
"We also explored the impact of the kinase activity of BUB1b on the recruitment of OTUD3 and NRF2."
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"We found that the recruitment of OTUD3 to NRF2 by BUB1b stabilized the protein level of NRF2 and enhanced resistance to ferroptosis, which conferred chemoresistance to LUAD."
39043653
sparser
"Mechanistically, BUB1b forms a complex with OTUD3 and NRF2 and stabilizes the downstream NRF2 signaling pathway to facilitate insensitivity to ferroptosis and chemotherapy."
39043653
sparser
"The interaction of NRF2 and OTUD3 was further confirmed by Co-IP, and it was shown that NRF2 could form a complex with OTUD3, which was abolished by the knockdown of BUB1b (Fig. xref )."
39043653
sparser
"Thus, the interaction of OTUD3 and NRF2 was BUB1b dependent."
39043653