IndraLab

Statements

BAP1 decreases the amount of EZH2. 7 / 7
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"BAP1 loss led to reduced L3MBTL2 stability and increased EZH2 transcription."
36900330
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"In contrast to the reduction of H3K27me3 seen with Asxl1 loss, Bap1 deletion leads to increased Ezh2 expression, higher levels of H3K27me3, and enhanced repression of PRC2 target genes in hematopoietic cells."
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"In both cell lines, replenishment of BAP1 level induced decreased EZH2 level and vice versa (Fig 3C)."
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"In mesothelioma, BAP1 loss promotes EZH2 expression [34], but the opposite association was seen in our data (i.e., BAP1 loss was significantly associated with <80% EZH2 expression)."
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"BAP1 loss leads to upregulated EZH2 expression, contributing to aberrant H3K27me3 levels and disrupted differentiation pathways, as observed in hematopoietic stem cells (HSC) and mesothelioma ."
39191942
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"BAP1 loss leads to increased expression of EZH2 (15)."
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"In mouse models, the loss of BAP1 leads to elevated enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) expression and enhanced repression of polycomb repressive complex 2 (PRC2) targets [48]."
38136262