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YOD1 activates ERAD. 2 / 2
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"The ER chaperone heat shock protein family A member 5 (also known as BiP/GRP78) and deubiquitinase YOD1 mediate both ER-RQC and ERAD pathways (66)."

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"Ubiquitin thioesterase OTU1, which is involved in the UPR and participates in the ubiquitin-related ERAD process (Gaudet et al., 2011), was significantly increased in this study (ratio = 1.2102), indicating the enhancement of ERAD to ameliorate ER pressure."