IndraLab

Statements

USP7 inhibits homeostatic process. 4 / 4
| 4
reach
"XREF_BIBR, XREF_BIBR Indeed, recent findings suggest that haploinsufficiency or duplications of HAUSP disrupt neuronal homeostasis, giving rise to neurological and behavioral abnormalities, such as seizures, aggressiveness, hypotonia, intellectual disability, hypogonadism with clinical features of autism spectrum disorder and a condition similar to Schaaf-Yang syndrome."
29967688
reach
"Novel oncogenic mutations in the TP53, BRCA2, PTEN, IL7R, RAS, NOTCH1, ETV6, BCL11B, WT1, DNMT3A, PRC2, PHF6, USP7, KDM6A and an array of other genes disrupt the genetic and epigenetic homeostasis in T-ALL."
33634864
reach
"USP7 silencing restored the expression of fatty acid metabolism-related proteins and restored mitochondrial homeostasis by inhibiting mitochondrial fission and promoting fusion events."
38815879
reach
"The selective inhibitor of USP7, P5091, has also been found to promote bone repair and homeostasis in osteoporotic conditions."
39651622