IndraLab

Statements

Haloperidol inhibits KCNH2. 17 / 17
5 4 | 8
reach
"In contrast, haloperidol blocked HERG channels potently with an IC50 value of approximately 1 microM."
9138706
ctd
No evidence text available
16494862
reach
"One of these agents, haloperidol, has already been shown to produce a high affinity blockade of HERG K + channels [22] but the effects of the two others still remain poorly investigated."
11377395
ctd
No evidence text available
15671647
reach
"Haloperidol, pimozide, and fluspirilene inhibited HERG current with IC (50) of 1.36, 1.74, and 2.34 microM, and maximal block of 73%, 76% and 65%, respectively."
11377395
tas
No evidence text available
21185626
ctd
No evidence text available
14678746
tas
No evidence text available
15911273
tas
No evidence text available
15324906
ctd
No evidence text available
16278312
reach
"The mechanism of HERG blockade by haloperidol may also involve interaction with the channel in inactivated state [22]."
11377395
reach
"For comparison, haloperidol (30 nM) and olanzapine (300 nM) reduced hERG current amplitude by 44.2 +/-3.9% and 49.7 +/-4.2%, respectively."
16494862
reach
"However, with up to 5 muM testosterone and up to 12 hr of incubation, enough oocytes with acceptable membrane properties (input resistance of no less than 2 x 10 5 Omega at -80 mV) were available.Appl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11377395
reach
"This analysis shows that enhancements of endogenous HF oscillations in HR were also found in beagle dogs with dofetilide and with other hERG blockers such as cisapride, haloperidol, risperidone, DL sotalol, terfenadine and thioridazine."
25625756
tas
No evidence text available
19534531
reach
"The inactivation attenuated mutant S631A reduces hERG drug block by haloperidol."
24471705
tas
No evidence text available
23919353