IndraLab

Statements

Haloperidol inhibits KCNH2. 11 / 20
5 4 | 11
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"In contrast, haloperidol blocked HERG channels potently with an IC50 value of approximately 1 microM."
9138706
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"Haloperidol was reported to block the HERG (human ether a-go-go related gene)-channels, that are responsible for the rapid component of delayed rectifier current I Kr , expressed in HEK (human embryon[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17045259
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"The haloperidol block of HERG was use- and voltage-dependent, suggesting a preferential binding to either the open or inactivated states of channels ( Suessbrich et al., 1997 )."
24998874
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"This analysis shows that enhancements of endogenous HF oscillations in HR were also found in beagle dogs with dofetilide and with other hERG blockers such as cisapride, haloperidol, risperidone, DL sotalol, terfenadine and thioridazine."
25625756
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"The inactivation attenuated mutant S631A reduces hERG drug block by haloperidol."
24471705
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"Haloperidol blocked hERG channels more potently than other cardiac potassium channels ( Testai et al., 2010 ), which indicates an important role of I Kr blockade by antipsychotics in mediating QT prol[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22565090
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"One of these agents, haloperidol, has already been shown to produce a high affinity blockade of HERG K + channels [22] but the effects of the two others still remain poorly investigated."
11377395
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"However, with up to 5 muM testosterone and up to 12 hr of incubation, enough oocytes with acceptable membrane properties (input resistance of no less than 2 x 10 5 Omega at -80 mV) were available.Appl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11377395
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"The mechanism of HERG blockade by haloperidol may also involve interaction with the channel in inactivated state [22]."
11377395
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"Unlike moxifloxacin, potent hERG blockers like haloperidol (an antipsychotic agent) and MK-499 (a class III antiarrhythmic) are not used in TCQT studies because of their undesirable safety profile tha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17643323
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"In another study, haloperidol blocked human HERG channels potently with an IC -value of approximately 1 µM [129]."
36902474