IndraLab

Statements

OTUB2 deubiquitinates YAP1. 8 / 8
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"Taken together, these data suggest that OTUB2 deubiquitylates YAP and promotes its stability in VSMCs."
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"Another three DUBs, ubiquitin carboxyl-terminal hydrolase 10 (USP10), otubain-2 (OTUB2) and ubiquitin carboxyl-terminal hydrolase 47 (USP47) deubiquitinate YAP/TAZ, playing important roles in hepatocellular carcinoma, breast cancer and colorectal cancer, respectively21 32 33."
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"As shown, KRAS expression diminished YAP/TAZ poly-ubiquitination in control HEK293T cells, but not in OTUB2-depleted cells ( Figure S7 B), confirming that OTUB2 mediates YAP/TAZ deubiquitination by RA[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"OTUB2 activates YAP/TAZ by directly deubiquitinating and stabilizing both YAP and TAZ."
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"Deubiquitination of YAP/TAZ by OTUB2 depends on the presence of a poly-SUMO chain conjugated to OTUB2 lysine 233, as SUMOylation enables OTUB2 interaction with a novel SUMO-interacting motif (SIM) ide[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"OTU deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2) promotes tumor stemness and metastasis by deubiquitinating and activating YAP/TAZ through a Hippo-independent pathway [ 24 ]."
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"Complementary, depletion of endogenous OTUB2 increased YAP/TAZ ubiquitination ( Figure S4 D)."
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"Mechanistically, OTUB2 deubiquitylated YAP and promoted its nuclear translocation, leading to increased PFKFB3 expression."
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