IndraLab

Statements

Ubv.B1.1 binds OTUB1. 3 / 3
| 3
reach
"Although Ubv.B1.1 binds to OTUB1 much more tightly than wt Ub, it showed a compromised ability to promote complex formation, suggesting an alteration in the binding mode."
24239534
reach
"Although Ubv.B1.1 binds to OTUB1 much more tightly than does Ub.wt, it shows a compromised ability to promote complex formation (XREF_FIG), suggesting an alteration in binding mode to OTUB1 relative to Ub.wt."
23287719
reach
"Purified Ubv.B1.1 bound to OTUB1 with a dissociation constant (K d) of 20 nM (XREF_SUPPLEMENTARY) and efficiently inhibited the cleavage of K48 linked di-Ub (XREF_SUPPLEMENTARY), which is consistent with a substrate-competitive binding mode."
23287719