IndraLab

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USP4 deubiquitinates HUWE1. 12 / 13
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"USP4 interacts directly with and deubiquitinates ARF-BP1, leading to the stabilization of ARF-BP1 and subsequent reduction of p53 levels."
21522127
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"USP4 interacts directly with and deubiquitinates ADP-ribosylatibon factor-binding protein 1 (ARF-BP1), leading to the stabilization of ARF-BP1 and subsequent reduction of p53 levels [12] ."
23313255
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"For instance, USP4 is reported to participate in the control of p53-related signaling through deubiquitinating ARF-BP1 , the suppression of canonical Wnt signaling pathway through deubiquitinating TCF4 , the activation of TGF-β signaling through deubiquitinating substrates like TβR-I and SMAD4 and the inhibition of NF-κB pathway through deubiquitinating mediators like TRAF2, TRAF6 and TAK1 ."
38734703
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"USP2 deubiquitinates both MDM2 and MDMX [XREF_BIBR, XREF_BIBR] whereas USP4 deubiquitinates ARF-BP1 [XREF_BIBR], another ubiquitin ligase for p53, thus indirectly destabilizing p53 and inhibiting its function."
28035068
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"Furthermore, USP4 interacts directly with and deubiquitinates ARF-BP1, leading to the stabilization of ARF-BP1 and subsequent reduction of p53 levels [XREF_BIBR]."
25972356
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"USP4 also interacts directly with and deubiquitinates ARF-BP1, leading to the stabilization of ARF-BP1 and subsequent reduction of p53 levels."
28791349
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"USP4 also regulates p53 stability via direct deubiquitination of the E3 ARF-BP1 [179] ."
22033037
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"For example, USP4 interacts directly with and deubiquitinates ARF binding protein 1 (ARF-BP1), leading to the stabilization of ARF-BP1 and subsequent reduction of p53 levels."
26411366
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"Recently, ARF-BP1 was reported to specifically target HDAC2 for ubiquitination and degradation and USP4 deubiquitinates and stabilizes ARF-BP1."
26411366
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"Nonetheless, USP4 might deubiquitinate and stabilize both ARF-BP1 and its substrate HDAC2."
26411366
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"USP4 is a deubiquitinating enzyme which may inhibit p53 by deubiquitinating an important p53 ubiquitin ligase ARF-BP1 [35]."
31987030
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"USP4 interacts directly with and deubiquitinates ADP-ribosylatibon factor binding protein 1 (ARFBP1), which results in the stabilization of ARF-BP1 and the subsequent reduction of p53 levels."
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