IndraLab

Statements


USP8 inhibits TARDBP. 3 / 3
| 3

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"Furthermore, knockdown of UBPY promotes formation of insoluble TDP-43 aggregates and induced neurotoxicity in D. melanogaster."

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"In contrast with α-synuclein [79], USP8 deficiency enhanced TDP-43 neurotoxicity in Drosophila."

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"In Drosophila melanogaster, UBPY silencing enhanced neurodegenerative TDP-43 phenotypes and the accumulation of insoluble high molecular weight TDP-43 and ubiquitin species."