IndraLab

Statements

PBRM1 binds BAP1 and SETD2. 2 / 2
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"In fact this association with chromosome 3p loss has recently been strengthened by several publications demonstrating that 4 out of five ( VHL , PBRM1 , SETD2 and BAP1 ) of the most frequently mutated genes associated with CCRCC are on chromosome 3p xref – xref and that the mutation of either SETD2 , BAP1 or PBRM1 associates with poorer prognosis or progression in those patients xref , xref , xref ."
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"The mutations in the chromatin regulators PBRM1 , BAP1 , and SETD2 were differentially associated with altered expression patterns of large numbers of genes when compared to samples bearing a background of VHL mutation ( xref , xref )."
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