IndraLab

Statements

THBS1 binds OTUD5. 14 / 14
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"Salvianolic acid B inhibits GPX4 ubiquitination by disrupting the interaction between THBS1 and OTUD5."
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sparser
"These findings support the hypothesis that the interaction between THBS1 and OTUD5 mediates increased GPX4 ubiquitination; however, the precise mechanisms require further experimental validation."
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"Finally, the precise details of the interaction between THBS1 and OTUD5 remain undefined and will be the focus of our future research."
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"Our study revealed that THBS1 in AMφ-derived exosomes interacted with OTUD5 in endothelial cells, leading to increased GPX4 ubiquitination."
39994679
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"Salvianolic acid B inhibits GPX4 ubiquitination by disrupting the interaction between THBS1 and OTUD5."
39994679
sparser
"Finally, the precise details of the interaction between THBS1 and OTUD5 remain undefined and will be the focus of our future research."
39994679
sparser
"SAB treatment inhibited the interaction between THBS1 and OTUD5, leading to reduced GPX4 ubiquitination."
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"Mechanistically, THBS1 interacted with OTUD5 to promote GPX4 ubiquitination, thereby increasing the sensitivity of endothelial cells to ferroptosis and contributing to endothelial barrier disruption."
39994679
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"These findings suggest that SAB inhibits GPX4 ubiquitination by interfering with the interaction between THBS1 and OTUD5."
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"These findings support the hypothesis that the interaction between THBS1 and OTUD5 mediates increased GPX4 ubiquitination; however, the precise mechanisms require further experimental validation."
39994679
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"These findings suggest that SAB inhibits GPX4 ubiquitination by interfering with the interaction between THBS1 and OTUD5."
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"The mechanism by which THBS1 binds directly to OTUD5 and promotes GPX4 ubiquitination was elucidated using RNA interference, adeno-associated virus transfection, and endothelial-specific Gpx4 knockout mice."
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"SAB treatment inhibited the interaction between THBS1 and OTUD5, leading to reduced GPX4 ubiquitination."
39994679
sparser
"The mechanism by which THBS1 binds directly to OTUD5 and promotes GPX4 ubiquitination was elucidated using RNA interference, adeno-associated virus transfection, and endothelial-specific Gpx4 knockout mice."
39994679