IndraLab

Statements

AKT activates USP22. 3 / 3
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"In addition to USP22, many other downstream factors, such as breast cancer resistance protein of AKT, are involved in drug resistance of breast cancers (56); therefore, future works are needed to dissect each substrate of phosphatidylinositol 3-kinase–AKT pathways in breast cancer tumorigenesis.One unexpected observation is the EPI-induced posttranscriptional stabilization of USP22, the cancer stem cell gene with increased expression in breast cancer stem cells (18)."
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"In addition, the deubiquitinase-inactive mutation completely abolished AKT-mediated USP22 stabilization."
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"These findings suggest that SOS1/RAS and downstream ERK and PI3K/AKT pathways mediate the oncogenic role of USP22 in gastric cancer."
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