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BRCC3 activates ferroptosis. 2 / 2

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"We found that BRCC36 overexpression upregulated the expression of GPX4 and HMGCR, while decreasing the levels of 4‐HNE (4‐hydroxy‐2‐noneal), a biomarker of ferroptosis (Figure 6I,J), indicating BRCC36 inhibits ferroptosis in HCC."

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"Since HMGCR is a key suppressor of ferroptosis and a substrate of BRCC36, we hypothesized that HMGCR is involved in BRCC36‐mediated ferroptosis and pyroptosis."

38178583

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IndraLab

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BRCC3 activates ferroptosis. 2 / 2

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