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USP8 inhibits GPX4. 2 / 2

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"In addition, overexpression of USP8 repressed ferroptosis by regulating glutathione peroxidase 4 and acyl-CoA synthetase long-chain family 4 expressions in COPD mice."

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"Professor Li and his team found that USP8 antagonized ferroptosis by stabilizing GPX4 in tumor cells and indicated that targeting USP8 may serve as a potential therapeutic strategy to promote ferroptosis to enhance cancer immunotherapy [96]."

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IndraLab

Statements

USP8 inhibits GPX4. 2 / 2

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