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Mangiferin inhibits NLRP3. 6 / 6
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"Mangiferin inhibits hippocampal NLRP3 inflammasome and exerts antidepressant effects in a chronic mild stress mice model."
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"Recent studies have shown that Mangiferin inhibits NLRP3 inflammasome in liver and endothelial cells to protect against liver injury and endothelial dysfunction XREF_BIBR XREF_BIBR."
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"The results showed that mangiferin treatment significantly reduced NO, IL-1beta, IL-6 and TNF-alpha production, also reduced the mRNA and protein of iNOS and COX-2, promoted the polarization of inflammatory toward anti-inflammatory, and inhibited activation of NF-kappaB and NLRP3 inflammasome."
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"Moreover, Mangiferin restored insulin mediated Akt and eNOS phosphorylations with increased NO production, immunohistochemistry examination of adipocytes, and endothelial tissue in high-fat diet fed mice also showed that oral administration of Mangiferin inhibited ER stress and NLRP3 induction in PVAT, and then effectively prevented insulin resistance in the vessel endothelium."
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"In conclusion, mangiferin protected against LPS and GalN induced liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation."
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"For example, Fan et al. [7] show that mangiferin attenuates TBI by inhibiting NLRP3 inflammasome."
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