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Mangiferin inhibits NLRP3. 12 / 12
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"Our results showed that mangiferin attenuated LPS/GalN-induced liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation.Serum ALT and AST were used as biochemical indic[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, it was reported that mangiferin can reduce inflammatory response by inhibiting NLRP3 inflammasome in an NF-κB-dependent manner in macrophages [28]."
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"Moreover, Mangiferin restored insulin mediated Akt and eNOS phosphorylations with increased NO production, immunohistochemistry examination of adipocytes, and endothelial tissue in high-fat diet fed mice also showed that oral administration of Mangiferin inhibited ER stress and NLRP3 induction in PVAT, and then effectively prevented insulin resistance in the vessel endothelium."
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"Mangiferin inhibits hippocampal NLRP3 inflammasome and exerts antidepressant effects in a chronic mild stress mice model."
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"Recent studies have shown that Mangiferin inhibits NLRP3 inflammasome in liver and endothelial cells to protect against liver injury and endothelial dysfunction XREF_BIBR XREF_BIBR."
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"Mangiferin inactivated NLRP3 inflammasome complex as well as its downstream signaling molecules and decreased COX-2, iNOS and TNF-α mediators [158] ."
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"Mangiferin could suppress pyroptosis by inhibiting NLRP3 pathway ( Feng et al., 2022 ; Li et al., 2022 )."
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"For example, Fan et al. [7] show that mangiferin attenuates TBI by inhibiting NLRP3 inflammasome."
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"However, this effect disappeared in mice with depleted microglia, indicating that NLRP3 inflammasome is involved in the inflammatory response to TBI, and MCC950’ s specific inhibition of NLRP3 inflammasome may be a promising therapeutic approach for TBI.In addition, JC124, HET0016, ACT001, pathenolide, mangiferin, propofol and other drugs have been reported to reduce the activation of NLRP3 inflammasome and caspase-1 around injury in TBI mice, and alleviate neurological deficits and neuronal damage [48–52]."
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"The results showed that mangiferin treatment significantly reduced NO, IL-1beta, IL-6 and TNF-alpha production, also reduced the mRNA and protein of iNOS and COX-2, promoted the polarization of inflammatory toward anti-inflammatory, and inhibited activation of NF-kappaB and NLRP3 inflammasome."
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"Here, we found that mangiferin can alleviate brain damage in rats suffering blast-induced traumatic brain injury, along with the down-regulation of NLRP3 inflammasome expression, which shed new light [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, mangiferin has been indicated to reduce lipopolysaccharide- and D-galactosamine-induced liver injury by inhibiting inflammation and oxidative stress via suppression of NLRP3 and activation of Nrf2(36)."
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