IndraLab

Statements

Kaempferol oxoanion inhibits NFKB1. 3 / 3
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"While kaempferol decreased NFkB activation in vivo, we did not see a significant difference in inflammatory genes known to be mediated by NFkB activation (data not shown)."
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"At the same time, kaempferol can inhibit the activation of IKKbeta, block the phosphorylation of IkappaBalpha, prevent NF-KB entering into the nucleus, and then decrease the release of inflammatory mediators."
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"Additionally, since kaempferol has previously been found to inhibit NFkB, a known mediator of inflammatory signaling XREF_BIBR, we incidentally observed that 15muM kaempferol decreased the phosphorylation of NFkB P65 (P-P65) relative to total P65 in renal tubular cells (N = 3 in each condition, P = 0.022, XREF_FIG)."
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