IndraLab

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USP3 inhibits Infections. 3 / 3
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"To examine why the ZNF domain of USP3 lacking deubiquitination activity also stabilizes A3G and inhibits HIV-1 infection, we performed deubiquitination experiments in vivo and in vitro."
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"Further experiments found that USP3 indeed inhibited HIV-1 infection by stabilizing A3G in a dose-dependent manner, although it had no effect on HIV production in the absence of A3G."
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"The results showed that USP3 WT, ZNF domain, and UCH domain all stabilized the expression of A3G [Figure 2F] and inhibited HIV-1 infection [Figure 2G]."
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