IndraLab

Statements

HAUS3 binds KCNQ5. 4 / 4
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"The top 10 hub genes in the yellow module included: BAF chromatin remodeling complex subunit BCL11A (BCL11A); SSBP3 antisense RNA 1 (SSBP3-AS1); EBF transcription factor 3, KCNQ5 intronic transcript 1 (KCNQ5-IT1); uncharacterized LOC101929633 (LOC101929633); carbonic anhydrase 2 (CA2); ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; roundabout guidance receptor 1 (ROBO1); INSM transcriptional repressor 2; and leucine rich repeat LGI family member 2 (LGI2)."
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"Regarding the lncRNA KCNQ5-IT1, it was only reported in array studies and was higher expressed in ALL, AML and CML patients in comparison to control group ( Lajoie et al., 2017; Lei et al., 2018; Zeng[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Results of RT-qPCR showed that the levels of lncRNAs MTCO2P12, KCNQ5-IT1 and RP11-83J16.1 were increased, whereas lncRNAs LINC00570, RP11-342M1.6, and REXO1L4P were decreased in RA patients compared to controls."
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"Although it is dysregulated in leukemia, few is known about the function of this lncRNA and more studies are necessary to better understand the involvement of KCNQ5-IT1 in this disease."
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