IndraLab

"Direct action could result from interaction of the sigma receptor with the Kv2.1 or other ion channels."

"The presence of potential 3 10 -helical character in the PrRP20 models may be a result of its amphipathic nature and the fact that the NMR data were also collected in SDS micelles at high PrRP20 concentration (0.5−15 mM). xref Indeed, there is evidence that amphipathic helices can assume extended (often 3 10 ) helical conformations in certain mediums, such as in detergent micelles. xref , xref Remarkably, it has been proposed that the R 1 xxR 2 xxR 3 xxR 4 xxR 5 xxR 6 motif in the Kv1.2- and Kv2.1-chimeric potassium ion channel structures form an extended 3 10 -helix, which allows the arginine residues to sit on the same side of the helix. xref , xref This is also often observed in our models of PrRP, which contains three arginine residues in an R 1 xxR 2 xxxR 3 motif."