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USP50 inhibits DNA2. 2 / 2
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"Further, since cells lacking FEN1 also show DNA2 and RECQL4/5-dependent suppression of replication restart, we suggest a model where USP50’s support of FEN1 restricts DNA2 and RECQL4/5 usage (Fig. 6A)."
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"In summary, in USP50-depleted cells, RECQL4, RECQL5 and DNA2 show aberrant localisation, suppress ongoing replication and promote spontaneous 53BP1 foci, they also suppress restart and increase ssDNA following exposure to HU."
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