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USP3 deubiquitinates TP53. 4 / 4
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"We observed that reconstitution of wildtype USP3 greatly suppressed p53 ubiquitination, while the C168S mutant did not affect p53 ubiquitination level ( Fig. 3 d–e)."
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"Depletion of <span class="match term0">USP3</span> lead to accelerated degradation of <span class="match term1">p53</span> in normal cells thereby enhanced cell proliferation and transformation"
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"USP3 deubiquitinates and stabilizes p53 and promotes normal cell transformation.U2OS Cells were maintained in Dulbecco's modified Eagle's medium (DMEM) containing 10% fetal bovine serum (Gibco, USA), [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We found that loss of USP3 dramatically enhanced p53 ubiquitination ( Fig. 3 a)."
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