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USP3 deubiquitinates TP53. 3 / 4
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"We observed that reconstitution of wildtype USP3 greatly suppressed p53 ubiquitination, while the C168S mutant did not affect p53 ubiquitination level ( Fig. 3 d–e)."
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"USP3 deubiquitinates and stabilizes p53 and promotes normal cell transformation.U2OS Cells were maintained in Dulbecco's modified Eagle's medium (DMEM) containing 10% fetal bovine serum (Gibco, USA), [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28807825
reach
"We found that loss of USP3 dramatically enhanced p53 ubiquitination ( Fig. 3 a)."
28807825