IndraLab

Statements

KCNMA1 binds IL17RB. 3 / 3
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reach
"Re-introducing WT CRBN but not mutant CRBN R419X in these KO cells restored both the binding to CRL4 and the half-life of Slo1 (XREF_FIG; XREF_SUPPLEMENTARY)."
29370161
sparser
"Here we report that ID-associated CRL4 CRBN mutations abolish the interaction of the BK channel with CRL4, and redirect the BK channel to the SCF Fbxo7 ubiquitin ligase for proteasomal degradation."
29370161
reach
"Deletion of CRBN resulted in the dissociation of Slo1 from binding to CRL4 (XREF_FIG) and a profound decrease of the half-life of the exogenously expressed Slo1 (XREF_FIG)."
29370161