IndraLab

Statements

IL17RB binds KCNMA1. 3 / 3
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"Deletion of CRBN resulted in the dissociation of Slo1 from binding to CRL4 (XREF_FIG) and a profound decrease of the half-life of the exogenously expressed Slo1 (XREF_FIG)."
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sparser
"Here we report that ID-associated CRL4 CRBN mutations abolish the interaction of the BK channel with CRL4, and redirect the BK channel to the SCF Fbxo7 ubiquitin ligase for proteasomal degradation."
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reach
"Re-introducing WT CRBN but not mutant CRBN R419X in these KO cells restored both the binding to CRL4 and the half-life of Slo1 (XREF_FIG; XREF_SUPPLEMENTARY)."
29370161