IndraLab

Statements

NOTCH1 increases the amount of USP11. 3 / 3
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"Based on our finding that NOTCH1 transcriptionally activates USP11 expression, it might be interesting to study the USP11-NOTCH1 positive feedback loop in other cancer types, including colorectal and breast cancer."
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"Furthermore, depletion of Notch1 by two independent siRNAs also increased USP11 and PML expression (XREF_FIG)."
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"Taken together, we identified a feedback loop regulation between USP11 and NOTCH1, in which NOTCH1 transcriptionally activates USP11 expression and, in turn, USP11 controls NOTCH1 protein levels via deubiquitination.Here, we identified a regulatory feedback loop between NOTCH1 and the USP11 deubiquitinase in T-cell acute lymphoblastic leukemia (T-ALL)."
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