IndraLab

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Lamotrigine activates SCN1A. 2 / 2
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"Specifically, Scn1a +/- mice treated with lamotrigine (20mg/kg/day) beginning at age P18 exhibited significantly more spontaneous seizures during a video monitored period between P21 and P25 (223 seizures over 863hours, n = 9) than control animals (75 seizures over 958hours, n = 14, p = 0.0047)."
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"By contrast, lamotrigine, a widely used sodium channel blocking antiepileptic drug, caused Scn1a +/- mice to exhibit a higher seizure frequency consistent with observations made in human Dravet syndrome 12."
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