IndraLab

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Curcumin inhibits NLRP3. 50 / 50
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"Curcumin Reduces Neuronal Loss and Inhibits the NLRP3 Inflammasome Activation in an Epileptic Rat Model."
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"Moreover, Bay 11-7082 (a NF-kappaB-specific inhibitor) markedly reduced NLRP3 inflammasome activation, which was dramatically attenuated by curcumin treatment."
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"We found that curcumin significantly inhibited the activation of the JAK2/STAT3 pathway and NLRP3 inflammasome, as well as the occurrence of pyroptosis and fibrosis in AFB 1 -exposed duck livers."
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"A previous study showed that curcumin might inhibit the activation of NLRP3 inflammasome-dependent pyrolysis by upregulating SIRT1, which in so doing inhibits inflammation [84]."
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"Curcumin suppresses NLRP3 inflammasome activation and protects against LPS induced septic shock."
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"Curcumin Attenuates the Activation of the NLRP3 Inflammasome."
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"Given the effect of curcumin on the expression of NLRP3 inflammasome and regulation of TLR4/MyD88/NF-kappaB and P2X7R, we concluded that curcumin reduced NLRP3 inflammasome, cleaved caspase-1 induction, and consequently reduced IL-1beta secretion through TLR4/MyD88/NF-kappaB and P2X7R pathways in PMA induced macrophages; the schematic model is shown in Figure XREF_FIG."
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"Additionally , curcumin could effectively decrease the mRNA expression of proinflammatory cytokines ( IL-1beta , IL-6 , and TNF-alpha ) and suppress NF-kappabeta activation as well as inhibit the expression of P2X7 receptors , thus preventing NLRP3 activation ."
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"Our data indicated that curcumin can inhibit the NLRP3 inflammasomes via (at least patially) decreasing P2X7R."
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"Curcumin was able to inhibit the generation of ROS and NLRP3 inflammasome activation assessed by NLRP3 and caspase-1 expression, which resulted in a reduction of IL-1beta secretion."
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"Curcumin suppresses ER-stress and downregulates TXNIP/NLRP3 with the regulation of AMPK activity [120]."
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"Curcumin reduces inflammation in mice with the psoriasis model by inhibiting NLRP3 inflammatory bodies."
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"Our work showed that curcumin inhibited TXNIP and NLRP3 inflammasome activation by suppressing ER stress, and thereby protected neuronal cell survival from glutamate neurotoxicity.Brain ischemia induc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We found that NLRP3 expression and caspase-1 and IL-1beta cleavage were inhibited after curcumin treatment in HK-2 cells exposed to high glucose levels, showing that curcumin inhibits the activation of NLRP3 inflammasomes."
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"These results demonstrated that curcumin inhibited NLRP3 inflammasome activation under ER stress conditions."
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"Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-kappaB and P2X7R Signaling in PMA Induced Macrophages."
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"In in vivo experiments, gavage with curcumin (40–50 μg/ml) inhibited the activation of NLRP3 by triggering the SIRT1/Nrf2 pathway to abrogate the downstream cytokine expression, such as IL-1β, IL-6, IL-18, and TNF-α (Yin et al., 2018; Yin et al., 2020)."
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"These results indicated that curcumin suppressed NLRP3 inflammasome activation and thus inhibited inflammatory response.In addition to evoked inflammation, NLRP3 inflammasome activation is responsible[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To confirm whether curcumin inhibited NLRP3 inflammasome activation through P2X7R signaling cascade, the receptor was silenced."
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"Kong et al. demonstrated that curcumin reduced the formation of NLRP3 inflammasome and secretion of pro-inflammation mediators via TLR4 signaling cascade in macrophages (Kong et al., 2016)."
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"Curcumin suppressed the upregulation of NLRP3, caspase-1, pro-IL-1beta and IL-1beta proteins (XREF_FIG), the increased ratio of caspase-1 to procaspase-1 and IL-1beta to pro-IL-1beta (XREF_FIG), as well as the enhanced caspase-1 activity (XREF_SUPPLEMENTARY), but had no significant effect on procaspase-1 expression (XREF_FIG) in SHR derived VSMCs."
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"Curcumin can inhibit TLR signaling and downstream activation of NF-kappaB, STAT3, and NLRP3 Inflammasome."
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"In addition, curcumin reduced NLRP3 inflammasome activation in lupus-prone mice."
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"The purpose of this article is to investigate whether curcumin can effectively inhibit the NLRP3 inflammatory body and thereby reduce the inflammation in the mouse psoriasis model."
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"Curcumin, a common suppressor of NLRP3 inflammasome activation, inhibits NLRP3 by stopping K efflux and interfering with downstream events, which in turn inhibits caspase-1 activation and IL-1β secretion [179]."
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"Our main finding indicates that the addition of curcumin concomitantly with LPS caused the greatest decrease in NLRP3 S glutathionylation and a respective increase in caspase-1 S glutathionylation, which appears to favor protein protein interactions in the NLRP3 complex."
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"In diabetic mice, the Nrf2 inducer curcumin decreased NLRP3 inflammasome activity, as reported by reduced protein levels of IL-1beta, cleaved caspase-1, and NLRP3 [XREF_BIBR]."
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"In addition , curcumin and PCB2 also could inhibit the expression of NLRP3 and have the potential to treat LN , according to the evaluation of anti-dsDNA antibody level and biochemical indexes ( Table 2 ) ."
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"Therefore, we hypothesized that curcumin inhibited the activation of the NLRP3 inflammasome via the mechanism of P2X7R."
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"Curcumin can not only reduce the NLRP3 expression and inhibit the inflammation caused by IL-22 and IL-18 but also reduce the damage of psoriasis ."
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"NLRP3 inflammasome activation was dramatically inhibited by curcumin in DSS stimulated macrophages, as evidenced by decreased IL-1beta secretion, less caspase-1 activation and ASC specks."
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"This is because curcumin has been shown to reduce NLRP3 inflammasome activation and IL-1beta production in lipopolysaccharide induced septic shock [XREF_BIBR], and both IL-1beta (a proinflammatory cytokine) and NLRP3 inflammasomes have been shown to be involved in the development of DN [XREF_BIBR, XREF_BIBR]."
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"Curcumin treatment prevented ER stress and NLRP3 inflammasome activation in the hippocampus, indicating the potential molecular target for its action."
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"In a Wistar rat model of MSU-evoked gouty arthritis, curcumin produced salutary effects by inhibiting NLRP3 inflammasome suppression via repression of NF-κB signaling both in vitro and in vivo [196]."
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"As a possible molecular mechanism, they found that, in mice hippocampus, glutamate stimulation increased NLRP3 expression and the cleaved form of caspase-1 enzyme, while curcumin attenuated NLRP3 and cleaved caspase-1 expression."
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"Indeed previous reports suggest that curcumin can inhibit the NLRP3 inflammasome activation and subsequent release of mature IL-1beta both in J774A.1 cells, as well as murine peritoneal macrophages in in vivo experiments."
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"Curcumin, as well as TUDCA, attenuated NLRP3 and cleaved caspase-1 expression (Figs. 6 A & B), and as expected, reduced IL-1beta secretion."
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"Curcumin inhibited the NLRP3 inflammasome by preventing K + efflux and disturbing the downstream events, including the efficient spatial arrangement of mitochondria, ASC oligomerization, and speckle formation."
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"Another study showed that curcumin inhibited TXNIP and NLRP3 inflammasome activation by suppressing endoplasmic reticulum stress and thereby protected neuronal cell survival from glutamate neurotoxicity after ischemic insult [XREF_BIBR]."
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"Curcumin, as well as allopurinol, notably up-regulated miR-200a expression, accordingly, down-regulated TXNIP and inhibited NLRP3 inflammasome activation in fructose fed rat livers and fructose exposed BRL-3A and HepG2 cells."
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"In vivo data also showed that Curcumin alleviated TJ impairment in murine testes, improved D-gal-triggered spermatogenesis ability, and inactivated the NLRP3 inflammasome by virtue of the AMPK/SIRT3/mtROS/SOD2 signal transduction pathway."
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"Curcumin potently inhibits the activation of NLRP3 inflammasome which may contribute to its anti-inflammatory activity."
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"As a result from suppression of ER stress associated TXNIP induction, curcumin inhibited NLRP3 and caspase-1 activation, and thereby reduced IL-1beta secretion."
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"Conclusion : Curcumin inhibited NLRP3 inflammasome through suppressing TLR4/MyD88/NF-kappaB and P2X7R pathways in PMA induced macrophages."
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"Since inflammation is one of the important pathological mechanisms of hypoxia injury, curcumin may inhibit the activation of caspase-1 by inhibiting NLRP3 inflammasome, thereby reducing the maturation and release of IL-1, reducing the proliferation of inflammation-induced PASMCs, improving the remodeling of blood vessels, and ultimately reducing pulmonary artery pressure in PHA rats."
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"Importantly, in vivo data show that curcumin attenuated IL-1beta secretion and prevented high-fat diet induced insulin resistance in wide-type C57BL/6 mice but not in Nlrp3 -deficient mice."
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"Curcumin inhibits the activation of NLRP3 inflammasome-dependent pyroptosis through the upregulation of SIRT1 [45]."
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"Curcumin could directly restrain the assembly of NLRP3 inflammasome, or inhibits the activation of NLRP3 inflammasome by inhibition of NF-κB pathway, which may be one of the mechanisms of curcumin for the treatment of inflammatory diseases."
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"Curcuma phaeocaulis Inhibits NLRP3 Inflammasome in Macrophages and Ameliorates Nanoparticle-Induced Airway Inflammation in Mice."
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"Curcumin also inhibited the stressed induced P2X7R and NLRP3 inflammasome axis activation, along with the reduced transformation of pro-IL-1beta to mature IL-1beta."
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