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Curcumin inhibits NLRP3. 107 / 107
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"Curcumin reduces inflammation in mice with the psoriasis model by inhibiting NLRP3 inflammatory bodies."
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"Curcumin inhibits the activation of NLRP3 inflammasome-dependent pyroptosis through the upregulation of SIRT1 [45]."
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"Consistent with previous studies, in this study, we found that curcumin inhibited NLRP3 inflammasome/IL-1β in vivo in lupus-prone mice and in vitro in anti-dsDNA+ serum-induced podocytes."
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"In vivo data also showed that Curcumin alleviated TJ impairment in murine testes, improved D-gal-triggered spermatogenesis ability, and inactivated the NLRP3 inflammasome by virtue of the AMPK/SIRT3/mtROS/SOD2 signal transduction pathway."
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"Moreover, Curcumin and mito-TEMPO significantly decreased NLRP3 and IL-1β in terms of the protein expressions, as well as IL-1β release, in D-gal-treated SCs, while the results combined with compound C as the AMPK inhibitor and 3-TYP as the SIRT3 inhibitor showed that the inhibition effect of Curcumin was repressed (Figures 5(b)–5(d))."
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"In addition, studies have shown that some natural drugs, including curcumin, chamomile lactone, Bay11‐7082, oridonin, and flavonoids, exert anti‐inflammatory functions by inhibiting NLRP3."
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"Moreover, curcumin could further alleviate CCH-induced apoptosis, and reduce nod-like receptor protein 3(NLRP3)-dependent pyroptosis, thereby improving secondary brain damage and behavioral disorders after CCH (Zheng Y. et al., 2021)."
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"Curcumin, another promising compound, inhibits NLR family pyrin domain-containing 3 (NLRP3) inflammasome-mediated spinal inflammation, enhances NRF2/GPX4 antioxidant responses, and reduces mitochondrial ROS production."
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"Apart from inhibiting NF‐κB signaling, curcumin also inhibits NLRP3 inflammasomes by attenuating K + efflux, preventing Ca 2+ influx and by preventing the binding of ASC adapter to NLRP3, thereby disr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Our data imply that the anti-inflammatory effect on ALI by curcumin is attributed to the inhibition of NLRP3 inflammasome-dependent pyroptosis activation, while the pathway of NLRP3 inhibition by curc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Curcumin suppresses ER-stress and downregulates TXNIP/NLRP3 with the regulation of AMPK activity [120]."
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"Curcumin inhibits the activated TXNIP/NLRP3 axis in cultured PQ-treated WI-38VA13 cells."
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"Additionally, the expression of proteins in the TXNIP/NLRP3-mediated proinflammatory pathway was determined, and it was demonstrated that curcumin also significantly decreased activation of the NLRP3 inflammasome."
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"Curcumin is also used in the treatment of LN, and can inhibit NLRP3 and its downstream factors, reducing proteinuria and renal inflammation [49]."
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"Curcumin supplementation suppresses the activation of NLRP3 inflammasome, and thereby blocks caspase-1 and IL-1β cleavage in db/db mice indicating that curcumin may have a beneficial effect in diabeti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In this regard, they showed that curcumin, a histone acetylation inhibitor, prevented NLRP3 activation [49]."
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"In db/db mice, administration of curcumin significantly blocked the NLR family pyrin domain containing three inflammasome signaling (NLRP3) and reduce DN progression [7]."
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"Moreover, in LPS induced septic shock experimental mouse models, it has been found that curcumin inhibits the activation of NLRP3 inflammasome and IL-1β production and improves the survival of mice su[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Our main finding indicates that the addition of curcumin concomitantly with LPS caused the greatest decrease in NLRP3 and increase in caspase-1 S-glutathionylation, which appears to favor protein-prot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Curcumin (10 μmol L ) inhibits the activation of the TXNIP/NLRP3 pathway by up-regulating AMPK activity in human neuroblastoma SH-SY5Y cells of human neuroblastoma and reducing ROS produced by endoplasmic reticulum stress (Li et al., 2015)."
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"By acting on peroxisome proliferator-activated receptor gamma and inhibiting the NF-κB pathway, curcumin directly suppresses the NLRP3 inflammasome, an intracellular complex involved in inflammatory disease development [11]."
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"Furthermore, curcumin inhibited NLRP3-related cell pyroptosis through autophagy, which was revised by the autophagy activator rapamycin (Yu et al., 2020)."
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"In the kidney of db/db mice, the NLRP3 inflammasome activity was repressed by curcumin [147]."
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"In a Wistar rat model of MSU-evoked gouty arthritis, curcumin produced salutary effects by inhibiting NLRP3 inflammasome suppression via repression of NF-κB signaling both in vitro and in vivo [196]."
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"Among several effective substances, curcumin, also called diferuloylmethane, is a principal curcuminoid of turmeric and has been demonstrated to inhibit the NLRP3 inflammasome observed in COVID-19 patients without any adverse effects (120)."
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"Curcumin, also called diferuloylmethane, is a principal curcuminoid of turmeric and has been demonstrated to inhibit the NLRP3 inflammasome observed in COVID-19 patients without any adverse effects [73]."
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"Curcumin inhibited NLRP3 activation by suppressing K+ efflux triggered by MSU and nigericin [45] ."
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"By regulating NF-κB signaling, curcumin effectively suppresses the NLRP3 inflammasome, whose critical role is emphasized by recent studies in the immunopathogenesis of severe COVID-19, especially in patients with an increased risk of the disease (e.g., diabetes and obesity)."
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"For instance, curcumin or melatonin have been shown to inhibit NLRP3 inflammasome and TLR4/MyD88/NF-κB signaling pathway respectively, reducing abdominal pain as well as acting like immune checkpoints in preclinical models of colitis [3,4,5]."
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"On the contrary, curcumin repressed NLRP3 (p < 0.01) and IL-1β (p < 0.001) while increasing PYCARD and IL-18 levels (p < 0.01) without altering caspase-1 expression (p > 0.05) in LoVo cells, indicating at least NLRP3-mediated pyroptosis is not involved in the anticancer efficacy of curcumin on this cell line but increased PYCARD and IL-18 levels may suggest that another inflammasome may be involved in this process (Figure 3c)."
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"Curcumin protected THP-1 and RAW264.7 cells from monosodium urate-induced mitochondrial damage by preventing the reduction of mitochondrial membrane potential, reducing mitochondrial reactive oxygen species, and then inhibiting the activity of the NLRP3 inflammasome."
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"Curcumin suppresses NLRP3 inflammasome activation and protects against LPS induced septic shock."
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"Curcumin, a common suppressor of NLRP3 inflammasome activation, inhibits NLRP3 by stopping K efflux and interfering with downstream events, which in turn inhibits caspase-1 activation and IL-1β secretion [179]."
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"The findings indicate that curcumin effectively inhibits NLRP3 inflammatory bodies, thereby reducing the expression of NLRP3 and suppressing IL-22- and IL-18-induced inflammation."
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"Curcumin potently inhibits the activation of NLRP3 inflammasome which may contribute to its anti-inflammatory activity."
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"Curcumin inhibits the activity of ubiquitin ligase Smurf2 to promote NLRP3-dependent pyroptosis in non-small cell lung cancer cells."
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"Curcumin can also decrease the activation of the TXNIP/NLRP3 inflammasome to prevent cell death (Zhang M. et al., 2021)."
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"Curcumin Reduces Neuronal Loss and Inhibits the NLRP3 Inflammasome Activation in an Epileptic Rat Model."
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"In conclusion, the findings of the present study showed that curcumin inhibited Smurf2 activity, thereby promoting NLRP3-dependent pyroptosis in NSCLC cells."
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"Curcuma phaeocaulis Inhibits NLRP3 Inflammasome in Macrophages and Ameliorates Nanoparticle-Induced Airway Inflammation in Mice."
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"Kong et al. demonstrated that curcumin reduced the formation of NLRP3 inflammasome and secretion of pro-inflammation mediators via TLR4 signaling cascade in macrophages (Kong et al., 2016)."
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"Curcumin inhibited the NLRP3 inflammasome by preventing K + efflux and disturbing the downstream events, including the efficient spatial arrangement of mitochondria, ASC oligomerization, and speckle formation."
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"Curcumin was able to inhibit the generation of ROS and NLRP3 inflammasome activation assessed by NLRP3 and caspase-1 expression, which resulted in a reduction of IL-1beta secretion."
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"Since inflammation is one of the important pathological mechanisms of hypoxia injury, curcumin may inhibit the activation of caspase-1 by inhibiting NLRP3 inflammasome, thereby reducing the maturation and release of IL-1, reducing the proliferation of inflammation-induced PASMCs, improving the remodeling of blood vessels, and ultimately reducing pulmonary artery pressure in PHA rats."
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"Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-kappaB and P2X7R Signaling in PMA Induced Macrophages."
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"In addition, curcumin can also suppress NLRP3 inflammasome (Figure 2) and pro–IL-1β synthesis by suppressing LPS-mediated activation of NF-κB signaling pathway[134]."
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"Additionally, the authors mentioned that curcumin may inhibit the activation of the NLRP3 inflammasome by inhibiting the ROS-TXNIP-NLRP3 pathway."
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"However, further studies are required to verify the mechanisms through which curcumin inhibits NLRP3 to improve EC pyroptosis."
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"Conclusion : Curcumin inhibited NLRP3 inflammasome through suppressing TLR4/MyD88/NF-kappaB and P2X7R pathways in PMA induced macrophages."
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"We found that curcumin significantly inhibited the activation of the JAK2/STAT3 pathway and NLRP3 inflammasome, as well as the occurrence of pyroptosis and fibrosis in AFB 1 -exposed duck livers."
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"In LPS-stimulated mouse macrophages, curcumin inhibits the activity of the NLRP3 inflammasome."
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"In in vivo experiments, gavage with curcumin (40–50 μg/ml) inhibited the activation of NLRP3 by triggering the SIRT1/Nrf2 pathway to abrogate the downstream cytokine expression, such as IL-1β, IL-6, IL-18, and TNF-α (Yin et al., 2018; Yin et al., 2020)."
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"Taken together, the ability of curcumin to inhibit NLRP3/caspase-1 activation leads to the downregulation of matured IL-1β, coupled with its cartilage-protective and anti-inflammatory activities, redu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Curcumin suppressed the upregulation of NLRP3, caspase-1, pro-IL-1beta and IL-1beta proteins (XREF_FIG), the increased ratio of caspase-1 to procaspase-1 and IL-1beta to pro-IL-1beta (XREF_FIG), as well as the enhanced caspase-1 activity (XREF_SUPPLEMENTARY), but had no significant effect on procaspase-1 expression (XREF_FIG) in SHR derived VSMCs."
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"Curcumin Attenuates the Activation of the NLRP3 Inflammasome."
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"The purpose of this article is to investigate whether curcumin can effectively inhibit the NLRP3 inflammatory body and thereby reduce the inflammation in the mouse psoriasis model."
35818215
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"Curcumin can not only reduce the NLRP3 expression and inhibit the inflammation caused by IL-22 and IL-18 but also reduce the damage of psoriasis ."
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"As a possible molecular mechanism, they found that, in mice hippocampus, glutamate stimulation increased NLRP3 expression and the cleaved form of caspase-1 enzyme, while curcumin attenuated NLRP3 and cleaved caspase-1 expression."
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"Therefore, we hypothesized that curcumin inhibited the activation of the NLRP3 inflammasome via the mechanism of P2X7R."
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"In our previous studies, we have shown that curcumin analogue, AI-44 can inhibit activation of NLRP3 inflammasome and improve LPS-induced sepsis in mice [17] ."
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"Importantly, in vivo data show that curcumin attenuated IL-1beta secretion and prevented high-fat diet induced insulin resistance in wide-type C57BL/6 mice but not in Nlrp3 -deficient mice."
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"Moreover, the in vivo experiments confirmed that curcumin inhibited NSCLC progression by modulating the Smurf2/NLRP3 axis, thereby offering a novel perspective for NSCLC treatment.However, the present study had certain limitations."
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"Additionally, curcumin prevents the activation of the NLRP3 inflammasome signaling pathway."
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"Additionally, curcumin can suppress the spatial formation of the NLRP3 inflammasome components [56]."
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"This is because curcumin has been shown to reduce NLRP3 inflammasome activation and IL-1beta production in lipopolysaccharide induced septic shock [XREF_BIBR], and both IL-1beta (a proinflammatory cytokine) and NLRP3 inflammasomes have been shown to be involved in the development of DN [XREF_BIBR, XREF_BIBR]."
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"We found that NLRP3 expression and caspase-1 and IL-1beta cleavage were inhibited after curcumin treatment in HK-2 cells exposed to high glucose levels, showing that curcumin inhibits the activation of NLRP3 inflammasomes."
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"These results were supported by in vivo studies, where curcumin (15, 30 and 60 mg/kg) and allopurinol (5 mg/kg) inhibited the activation of TXNIP/NLRP3 inflammasomes by up-regulating miR-200a in the l[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Curcumin attenuates aflatoxin B1-induced ileum injury in ducks by inhibiting NLRP3 inflammasome and regulating TLR4/NF-κB signaling pathway."
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"Curcumin represses NLRP3 inflammasome activation via TLR4 and MyD88 / NF-jB and P2X7R signaling in PMA induced macrophages."
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"In diabetic mice, the Nrf2 inducer curcumin decreased NLRP3 inflammasome activity, as reported by reduced protein levels of IL-1beta, cleaved caspase-1, and NLRP3 [XREF_BIBR]."
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"Indeed, curcumin inhibits NLRP3 activation induced by ischemic stroke in animal models of transient middle cerebral artery occlusion/reperfusion (MCAO/R) via an upstream regulatory mechanism."
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"Curcumin significantly represses inflammasome activation of NLRP3 and IL-1β production in DSS-stimulated macrophages."
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"Our data indicated that curcumin can inhibit the NLRP3 inflammasomes via (at least patially) decreasing P2X7R."
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"Moreover, Bay 11-7082 (a NF-kappaB-specific inhibitor) markedly reduced NLRP3 inflammasome activation, which was dramatically attenuated by curcumin treatment."
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"To confirm whether curcumin inhibited NLRP3 inflammasome activation through P2X7R signaling cascade, the receptor was silenced."
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"Indeed previous reports suggest that curcumin can inhibit the NLRP3 inflammasome activation and subsequent release of mature IL-1beta both in J774A.1 cells, as well as murine peritoneal macrophages in in vivo experiments."
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"Given the effect of curcumin on the expression of NLRP3 inflammasome and regulation of TLR4/MyD88/NF-kappaB and P2X7R, we concluded that curcumin reduced NLRP3 inflammasome, cleaved caspase-1 induction, and consequently reduced IL-1beta secretion through TLR4/MyD88/NF-kappaB and P2X7R pathways in PMA induced macrophages; the schematic model is shown in Figure XREF_FIG."
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"According to the current literature, curcumin could inactivate the NLRP3 inflammasome, thus exerting an anti-inflammatory effect."
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"The addition of curcumin reduced NLRP3 activity, accompanied by a decrease in the p-p65/p65 ratio and a significant decrease in the LC3II/LC3I ratio (Fig. 6C and E.880 ± 0.068 vs. 0.634 ± 0.056; p = 0.008, 0.828 ± 0.008 vs. 0.561 ± 0.051; p < 0.001, and 0.652 ± 0.084 vs. 0.397 ± 0.066; p = 0.010, respectively)."
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"Additionally, curcumin, ilexgenin A, and astragaloside IV can suppress TXNIP/NLRP3 inflammasome through their interaction with AMPK signalling [195,196,197]."
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"Curcumin, as well as TUDCA, attenuated NLRP3 and cleaved caspase-1 expression (Figs. 6 A & B), and as expected, reduced IL-1beta secretion."
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"These results indicated that curcumin suppressed NLRP3 inflammasome activation and thus inhibited inflammatory response.In addition to evoked inflammation, NLRP3 inflammasome activation is responsible[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Curcumin also inhibited the stressed-induced P2X7R/NLRP3 inflammasome axis activation, along with the reduced transformation of pro-IL-1β to mature IL-1β."
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"Curcumin represses NLRP3 inflammasome activation via TLR4/MyD88/NF-kappaB and P2X7R signaling in PMA induced macrophages."
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"Curcumin was also shown to inhibit the P2X7/NLRP3 inflammasome axis, reducing the CUMS-induced conversion of pro-IL-1β to mature IL-1β in the hippocampus of male Sprague Dawley rats [52]."
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"Our work showed that curcumin inhibited TXNIP and NLRP3 inflammasome activation by suppressing ER stress, and thereby protected neuronal cell survival from glutamate neurotoxicity.Brain ischemia induc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Curcuma phaeocaulis extract was shown to suppress caspase-1 activation and pro-IL-1β maturation in SiO - and TiO -nanoparticle-activated NLRP3 inflammasome in macrophages."
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"Curcumin could directly restrain the assembly of the NLRP3 inflammasome or inhibit the activation of the NLRP3 inflammasome through several classic pathways such as TLR4/MyD88/NF-kB and AMPK (128, 129)."
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"Curcumin, a principal and most active curcuminoid (87), attenuates the progression of diabetic nephropathy by limiting the activation of the NLRP3 inflammasome (88)."
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"As a result from suppression of ER stress associated TXNIP induction, curcumin inhibited NLRP3 and caspase-1 activation, and thereby reduced IL-1beta secretion."
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"These results demonstrated that curcumin inhibited NLRP3 inflammasome activation under ER stress conditions."
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"For example, in the heart of nephrectomized rats, curcumin prevented macrophage infiltration and reduced the inflammasome component levels NLRP3, apoptosis-associated speck-like (ASC), and caspase-1, preventing inflammasome activation."
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"Curcumin treatment prevented ER stress and NLRP3 inflammasome activation in the hippocampus, indicating the potential molecular target for its action."
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"Additionally , curcumin could effectively decrease the mRNA expression of proinflammatory cytokines ( IL-1beta , IL-6 , and TNF-alpha ) and suppress NF-kappabeta activation as well as inhibit the expression of P2X7 receptors , thus preventing NLRP3 activation ."
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"Curcumin suppresses NLRP3 inflammasome activation and protects against LPS induced septic shock."
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"Curcumin attenuates murine lupus by inhibiting NLRP3 inflammatory vesicles (12)."
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"Specifically, curcumin prevents activation of the NLRP3 inflammasome, suggesting that the NLRP3 inflammasome is a key mediator of curcumin's beneficial effects."
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"Curcumin, a polyphenol derived from turmeric (Curcuma longa) rhizome and commonly used as a spice and herb in Asia, reduces the EMT in bladder tissue and detrusor muscle fibrosis by inhibiting the NLR[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Curcumin specifically inhibits NLRP3 inflammasomes by blocking potassium efflux and interfering with mitochondrial transport and ASC polymerisation but not on the AIM2 or NLRC4 inflammasomes."
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"However, the specific mechanism is largely unknown at present.In this study, we found that curcumin attenuated inflammatory injury during ALI by inhibiting NLRP3 inflammasome-dependent pyroptosis."
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"Curcumin attenuates anti-dsDNA-induced NLRP3 inflammasome activation in podocytes.Anti-dsDNA can activate NLRP3 inflammasome."
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"Another study showed that curcumin inhibited TXNIP and NLRP3 inflammasome activation by suppressing endoplasmic reticulum stress and thereby protected neuronal cell survival from glutamate neurotoxicity after ischemic insult [XREF_BIBR]."
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"Curcumin can suppress the NLRP3 inflammasome and reduce insulin resistance caused by a high-fat diet [ 58 ]."
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"A previous study showed that curcumin might inhibit the activation of NLRP3 inflammasome-dependent pyrolysis by upregulating SIRT1, which in so doing inhibits inflammation [84]."
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"Some phytochemicals have demonstrated promise in blocking the NLRP3 inflammasome and managing LN, including curcumin, baicalein, sophocarpine, glycyrrhizic acid, and magnolol [201]."
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"Thus, curcumin inhibits NF-êB signaling and suppresses NLRP-3 activation (53)."
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"Curcumin inhibited NLRP3 inflammasome through suppressing TLR4/MyD88/NF-κB and P2X7R pathways in PMA-induced macrophages [ 30 ]."
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