IndraLab

Statements

USP27X activates AKT. 3 / 3
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"Taken together, USP27X‐AS1 upregulated AKT signalling via interacting with AKT protein.3.5 USP27X-AS1 inhibited AKT proteasome degradation."
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"In conclusion, USP27X‐AS1 upregulated AKT protein expression by recruiting USP7 to deubiquitinate AKT.3.6 USP27X-AS1 promoted HCC progression by regulating AKT."
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"Results showed that USP27X‐AS1 knockdown impaired AKT protein stability (Figure 5A1,B1 and Figure S5A1,B1), while USP27X‐AS1 overexpression prolonged the half‐life of AKT (Figure 5A2,B2 and Figure S5A2,B2), suggesting that USP27X‐AS1 might inhibit AKT degradation."
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