IndraLab

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OTUD4 activates Deubiquitinase. 6 / 6
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"The DUB-deficient mutant C45A also effectively rescued KSHV lytic reactivation (Fig 2F and 2G), confirming that OTUD4 promotes KSHV lytic reactivation independent of its DUB activity."
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"Collectively, these data indicate that OTUD4 promotes KSHV lytic reactivation independent of its DUB activity."
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"However, studies reported that the deubiquitase recruitment domain (DRD, 181–550aa) of OTUD4 interacts with and deubiquitinates ALKBH3 [41, 42], intrinsically disordered regions (IDRs, such as 885–1114aa) of OTUD4 interacts with RNA [43], the ubiquitin interaction motif (UIM, 271–300aa) of OTUD4 promotes its DUB activity against MyD88 [10]."
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"Phosphorylation of OTUD4 activates its K63-specific DUB activity [10]."
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"Based on these, we speculated that 301–550aa of OTUD4 is the catalytic domain for deubiquitination of CDK1, and 181–300aa of OTUD4 might promote the DUB activity of OTUD4 on CDK1 by enhancing their interaction ability.On the one hand, in order to identify which type of polyubiquitin modifications on CDK1 was affected by OTUD4, we performed a thorough deubiquitylation assay."
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"OTUD4 promotes KSHV lytic replication independent of its DUB activity."
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