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USP28 deubiquitinates FBXW7. 12 / 12
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"In addition, the autocatalytic ubiquitylation of Fbw7 can be antagonized by the deubiquitinase Usp28 [XREF_BIBR]."
28850619
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"To test whether Usp28 directly deubiquitinates Fbw7, we used an in vitro assay with immunopurified SCF (Fbw7) and recombinant E1 and E2 enzymes, which leads to the accumulation of autoubiquitinated Fb[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25437563
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"Indeed, experiments in MEFs and human tumor cells demonstrate that Usp28 directly deubiquitinates and stabilizes Fbw7."
27308481
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"We discuss mechanisms that regulate ubiquitination by Fbw7, including ubiquitin-specific proteases such as USP28 that counteract Fbw7 activity and thereby stabilise oncoproteins."
26410034
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"In addition, USP28 antagonizes FBW7 mediated ubiquitination and stabilizes HIF-1alpha [XREF_BIBR, XREF_BIBR]."
33466790
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"Usp28 preferentially deubiquitinates Fbw7 and at intermediate levels maintains stable Fbw7 but does not allow excessive Fbw7 substrate stabilization."
25437563
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"USP28 deubiquitinates and stabilizes FBW7 resulting in enhanced degradation of FBW7 substrates."
29880484
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"Ubiquitin specific peptidase 28 (USP28), a deubiquitinating enzyme can also repress autocatalytic ubiquitination and degradation of FBXW7 (Diefenbacher et al., 2014; Schulein-Volk et al., 2014)."
34512273
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"It was recently shown that the deubiquitinase Usp28 deubiquitinates and stabilizes Fbxw7 [XREF_BIBR]."
26426760
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"Indeed, wild-type Usp28, but not the catalytically inactive C171A mutant, promoted Fbw7 deubiquitination in vivo."
25437563
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"As USP28 deubiquitinates and stabilizes FBW7, allowing the FBW7 and SCF ligase complex to bind and degrade substrates containing a Cdc4 phosphodegron motif, we hypothesized that forced expression of USP28 would target BRAF for degradation."
29880484
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"In this setting, USP28 deubiquitinates the SCF component FBW7, allowing FBW7 to act as a substrate recognition factor targeting substrates for proteosomal mediated degradation."
29880484