IndraLab

Statements

Propofol inhibits HCN4. 2 / 2
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"As shown in a representative experiment in Figure 1A, propofol caused substantial inhibition of the HCN4 current; the effect was characterized by a reduction in the tail currents at 0 mV after hyperpolarizing voltage steps to different membrane potentials."
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"Propofol inhibited and slowed the activation of recombinant HCN1, HCN2, and HCN4 channels at clinically relevant concentrations, in which the HCN1 current was the most sensitive of the three."
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