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USP8 deubiquitinates PTEN. 2 / 2
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"This was further corroborated by evidence showing that USP8 overexpression eliminated the ubiquitination of PTEN protein (Fig. 5J)."

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"Taken together, we discovered that USP8 binds to PTEN protein, and consequently de-ubiquitinates and stabilizes PTEN protein."