IndraLab

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NEDD4L decreases the amount of KCNQ1. 2 / 3
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"As expected, silencing of Nedd4L in S-iPSC-CMs restored KCNQ1 protein levels."

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"As it has been recently shown that the ubiquitin protein ligase Nedd4-2 inhibits KCNQ1 plasma membrane expression and that AMPK regulates epithelial Na (+) channels via Nedd4-2, we examined the role of Nedd4-2 in the AMPK dependent regulation of KCNQ1."