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OTUD7B increases the amount of SOX2. 2 / 2

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"It was previously reported that Otud7b is a deubiquitinase that deubiquitinates and stabilizes Sox2 and promotes the maintenance of neural progenitor cells.61 Otud7b silencing decreases Sox2 levels and promotes neuronal differentiation in cultured cells."

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"The protein expression levels of SOX2 and Nanog, two stemness-associated proteins, were markedly suppressed by OTUD7B knockdown (Fig. 2A)."

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IndraLab

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OTUD7B increases the amount of SOX2. 2 / 2

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