IndraLab

Statements

OTUB1 deubiquitinates GPX4. 3 / 3
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"By recruiting OTUB1, which binds to GPX4, CST1 inhibits the ubiquitination and degradation of GPX4 protein, promotes protein stability, reduces intracellular reactive oxygen species, and protects cells against ferroptosis."
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"These results implied that CST1 mediates the deubiquitination of GPX4 by OTUB1."
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"The GPX4 ubiquitination and its protein destabilization can be prevented by cysteine protease inhibitor SN (CST1) via recruiting ubiquitin thioesterase OTUB1, resulting in gastric cancer progression [[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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