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Primaquine inhibits KCNH2. 4 / 4
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"Primaquine inhibited hERG current in a concentration dependent manner with the half-maximal inhibitory concentration (IC (50)) of 21.5 microM."
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"Blockade of hERG by primaquine was also found to be time dependent, occurring rather rapidly."
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"Primaquine inhibited hERG current in a concentration-dependent manner with the half-maximal inhibitory concentration (IC(50)) of 21.5 microM."
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"In conclusion, these results indicate that primaquine preferentially inhibits the hERG potassium channel, but blockade of hERG channel by primaquine may not be related to the S6 residue or the pore region, but may be induced through other pathways such as binding other region or effect by drug binding receptor which indicates a need for further exploration."
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