IndraLab

Statements

Hsp90 inhibitors activates KCNH2. 3 / 3
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"Hsp90 inhibitors have been shown to disrupt proper trafficking and function of hERG [XREF_BIBR]."
25367392
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"Previously, it was shown that Hsp90 inhibitors, such as geldanamycin and radicicol, cause both a dose dependent reduction in the hERG associated current amplitudes in patch clamp experiments and in the trafficking efficiency of hERG, or the ratio of fg hERG over total hERG (fg+ cg) (XREF_FIG)."
22554505
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"XREF_BIBR - XREF_BIBR Hsp90 inhibitors have been shown to disrupt hERG function and cause a reduction in hERG related membrane currents in in-vitro studies."
22554505