IndraLab

Statements

Procaine inhibits KCNH2. 3 / 3
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"Procaine, a state dependent blocker, inhibits HERG channels by helix residue Y652 and F656 in the S6 transmembrane domain."
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"Conclusively, procaine state-dependently inhibits HERG channels (WT, Y652A, and F656A)."
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"The results revealed that WT HERG is blocked in a concentration-, voltage-, and state dependent manner by procaine ([IC50] = 34.79 muM)."
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