IndraLab

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USP13 increases the amount of USP13. 6 / 6
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"In addition, Guo et al. reported that RREB1 is a TF of USP13, that promotes USP13 expression [49]."
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"The lentivirus overexpressing USP13 effectively upregulated the expression of USP13 compared with the control lentivirus (vector) and the control cells that did not undergo any treatment (Figure 2A)."
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"In addition, knockdown of USP13 reduced vimentin expression and invasion capacity in A549 cells expressing WT β-catenin but failed to inhibit vimentin and invasion in cells expressing K508R β-catenin [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To generate the LV-Usp13 or LV-shUsp13 vectors, the mouse Usp13 cDNA sequences or shRNA targeting mouse Usp13 sequences were loaded into pLenti-GFP-Puro-CMV or pLenti-U6-GFP (Addgene) to upregulate or downregulate USP13 expression in vivo experiments.2.9 Metabolic factors and serum cytokines parameters."
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"In addition, via bioinformatic analyses and molecular biology experiments, we revealed that Yin Yang 1 (YY1) is a new transcription factor of USP13 that promotes USP13 transcription through binding to its promoter region."
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"These results underscore a key role of Twist1 in a USP13-induced enhancement of migration and invasion capacities of breast cancer cells.We also assessed the effects of USP13 expression on lung metastasis of breast cancer to further substantiate the above in vitro findings."
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