IndraLab

Statements

Lipopolysaccharide decreases the amount of USP13. 10 / 10
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"We have shown that LPS reduced USP13 mRNA expression in Raw264.7 cells."
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"Interestingly, USP13 expression was decreased in human-FLSs after stimulation by LPS, TNF-α and IL-1β."
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"Furthermore, LPS reduced USP13 mRNA levels in Raw264.7 cells (L. Li et al., 2019)."
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"To further investigate molecular mechanisms of USP13 reduction in an inflammatory condition, we confirmed our published data and showed that intratracheal LPS challenge diminished USP13 protein levels in murine lungs (Fig. 1A and B)."
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"We found that LPS treatment of Raw264.7 cells diminished USP13 levels in both dose- and time-dependent manners (Fig. 1 H–K), consistent with our previous study."
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"To investigate the molecular mechanisms by which LPS reduces USP13 levels in macrophages in the liver, we examined the effect of LPS on USP13 levels in Kupffer cells."
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"LPS treatment starting from 10 ng/ml decreased USP13 levels after 24 h (Fig. 2A–D)."
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"The western blotting further confirmed that LPS reduces USP13 protein levels without altering its transcription (Fig. 3B), suggesting that LPS may affect USP13 protein stability."
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"We revealed that LPS reduces USP13 protein levels in both cell types, while USP13 mRNA is reduced in Raw264.7 cells, but not in Kupffer cells."
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"We have shown that LPS treatment decreased USP13 levels in mouse macrophage-like RAW264.7 cells ; however, the molecular regulation of USP13 during the development of pulmonary fibrosis has not been investigated."
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