IndraLab

Statements

SCN5A binds DLG1. 8 / 9
1 | 5 3
sparser
"The binding data illustrated the manipulation of intracellular Nav1.5 O-GlcNAc levels directly affected the interaction between Nav1.5 and SAP-97."
29530619
sparser
"In cardiomyocytes, SAP97 interacts with Nav1.5, a PDZ binding motif of SCN5A and others potassium channel subunits."
36833354
reach
"The interaction between SAP97 and Nav1.5 and Kir2.1/2 channels simultaneously regulates several trafficking and functional aspects of these channels."
36596415
sparser
"The interaction between SAP97 and Nav1.5 and Kir2.1/2 channels simultaneously regulates several trafficking and functional aspects of these channels."
36596415
reach
"SAP97 encoded by the DLG1 gene, the most well-characterized MAGUK protein in the myocardium, interacts with several ion channel families: KV1.5 [16,17], KV4.x [18,19], Kir2.x [20,21], and NaV1.5 [20,22]."
36833354
reach
"The binding data illustrated the manipulation of intracellular Nav1.5 O-GlcNAc levels directly affected the interaction between Nav1.5 and SAP-97."
29530619
reach
"We found that hyperglycemia could increase the O-GlcNAc modification of Nav1.5 and inhibited the interaction between Nav1.5 and Nedd4-2/SAP-97, eventually leading to the abnormal expression and distri[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29530619
reach
"Hyperglycemia increases the O-GlcNAcylation of Nav1.5 and reduces the interaction between Nav1.5 and Nedd4-2/SAP-97, leading to the abnormal expression and distribution of Nav1.5, loss of sodium channel function and prolongation of the PR/QT interval."
38790676