IndraLab

Statements

Pseudouridine inhibits RIGI. 5 / 5
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"Hence, one should keep in mind both points when creating mRNA vaccines.Alternatively, a reduction of immunogenicity can be attained by using modified bases such as pseudouridine or m1Ψ, which change mRNA secondary structures (hairpins) and thus prevent receptor TLR3 or RIG-I from recognizing mRNA [119]."
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"Moreover, N-6-methyladenosine (m6A) and pseudouridine within a polyU/UC RNA domain of hepatitis C virus were tested for cytosolic RIG-I stimulation and showed to reduce RIG-I signaling."
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"In addition, abundant cellular RNAs, such as tRNAs and rRNAs, are extensively modified with unusual bases, such as pseudouridine, which prevent the activation of RIG-I and MDA5 (Ref."
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"Furthermore, abundant cellular RNAs such as tRNAs and rRNAs are extensively modified with unusual bases such as pseudouridine that prevent activation of RIG-I and MDA-5 [26] ."
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"Additionally, the presence of m 6 A and pseudouridine in viral RNA was recently shown to attenuate the activation of the RIG-I innate signaling pathway."
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