Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SHC binds EGFR, GRB2, and IRS1. 2 / 2

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"24 GRB2 over-expression is particularly interesting in breast cancer because GRB2 can bind to tyrosine-phosphorylated EGFR, SHC, insulin receptor substrate-1, and HER2/neu,1'15'26'27 which have all be[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

11706405

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"Furthermore, we have identified a short sequence motif (YV/IN) present in IRS-1, EGFR and Shc, which specifically binds the SH2 domain of GRB2 with high affinity."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...