IndraLab

Statements


SHC binds EGFR, GRB2, and IRS1. 2 / 2
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"Furthermore, we have identified a short sequence motif (YV/IN) present in IRS-1, EGFR and Shc, which specifically binds the SH2 domain of GRB2 with high affinity."
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"24 GRB2 over-expression is particularly interesting in breast cancer because GRB2 can bind to tyrosine-phosphorylated EGFR, SHC, insulin receptor substrate-1, and HER2/neu,1'15'26'27 which have all be[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"