IndraLab

Statements

TNF increases the amount of CD4. 6 / 7
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"TNF and IFN-gamma, alone or in combination, did not cause any significant change of CD4 mRNA expression in HL-60 cells, thus indicating that decrease of surface CD4, which accompanies differentiation with these cytokines, is likely due to alterations of the CD4 protein synthesis and/or transport to the plasma membrane."
1628901
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"We also found that TNF-a could induce and maintain CD4 expression in L4E cells, although this is not the factor produced by SO stroma (32)."
7720091
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"Treatment of cultures with recombinant cytokines given at concentrations in the range of those induced by HIV-1 indicated that IL-6 and TNF alpha caused an increase of : i) CD4 expression, ii) HIV absorption to uninfected cells, and iii) release of infectious virions by infected cells."
8279951
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"This down-regulation of CD4 expression by LPS, TNF-alpha, and IL-1 beta occurs at the level of transcription."
7586702
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"We examined the hypothesis that one of the pro inflammatory cytokines, tumour necrosis factor-alpha (TNF-alpha), could induce expression of the adhesion molecule CD4 on human eosinophils."
8690465
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"Conversely, neither LPS nor TNF-alpha and IL-1 beta were able to modulate surface CD4 expression on quiescent or phytohaemagglutinin (PHA)-activated lymphocytes."
7586702