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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TP53 bound to MDM4 activates TP53. 2 / 2

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"13 Although MDMX is highly homologous to MDM2, Nutlin is inefficient in interrupting the transcription-repressive MDMX and p53 complex, which prevents p53 transcriptional activity in numerous cancer cell lines, including retinoblastomas, which harbor MDMX upregulation."

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"The association between MDM4 and p53 is evidenced in the cytoplasmic compartment, supporting the role of cytoplasmic stabilization of p53 during its activation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...