IndraLab

Statements

USP18 inhibits GSDMD-N. 3 / 3
| 3
reach
"These results suggest that it is feasible to investigate whether USP18/MIB2 can directly promote the degradation of GSDMD-N by employing the visually expressed I104N mutation."
38779488
reach
"Given the critical role of GSDMD-N in triggering pyroptosis and the location of K168 at the GSDMD-N, we sought to investigate whether USP18 and MIB2 could directly induce the degradation of GSDMD-N."
38779488
reach
"To investigate whether USP18 and MIB2 could directly promote the degradation of GSDMD-N, we examined whether the GSDMD I104N mutant altered the binding of USP18/MIB2 to GSDMD and whether its degradation was mediated by USP18/MIB2, ensuring the accuracy of subsequent experiments."
38779488