IndraLab

Statements

USP18 inhibits activation. 6 / 6
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"Luciferase assay showed that both human and mouse USP18 markedly inhibited MyD88-mediated NF-κB-luc activation, suggesting a conserved biological function in regulating the NF-κB signaling pathway ( xref )."
26240016
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"More importantly, USP18 only inhibited NF-κB activation in WT NEMO or NEMO (K285/309R) construct, but had no effect on NEMO (K325/326R) construct ( xref )."
26240016
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"Regardless of its enzymatic activity, UBP43 directly interacts with the IFNAR2 subunit of the IFN-α/β receptor such that UBP43 inhibits the activation of receptor-associated JAK1 by blocking the interaction between JAK1 and IFNAR2 [ xref ]."
22683641
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"Moreover, USP18 competitively inhibits IFN-α/β-induced JAK/STAT activation [ xref ] and upregulates epidermal growth factor receptor (EGFR) expression [ xref ]."
26046984
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"In contrast, USP18 did not inhibit p65-mediated NF-κB activation ( xref ), suggesting that USP18 inhibits the NF-κB pathway upstream of p65, most likely targeting the IKK complex."
26240016
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"Taken together, these results suggest that USP18 inhibits TLR-induced NF-κB activation by blocking the degradation of IκBα as well as by blocking the nuclear accumulation of p65."
26240016