IndraLab

Statements

USP37 is phosphorylated on T631. 4 / 4
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"Previous phosphospecific proteomics results have shown the presence of phosphorylation on Thr631 of USP37, which matches the consensus sequence for CDK substrates."
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"In vivo deubiquitination assays and in vitro kinase assays indicated that phosphorylation of USP37 at Ser628 had no regulatory effect on targeting SND1 for deubiquitination ( xref ), and CDK2-mediated phosphorylation of USP37 at Ser628 did not mediate the phosphorylation of USP37 at Thr631 ( xref )."
40486858
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"Hence, we sought to determine whether phosphorylation of USP37 at Ser628 enhances targeting for deubiquitination of SND1 and whether CDK2 could also mediate phosphorylation of USP37 at Thr631."
40486858
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"We then employed Scansite () to analyze the potential kinases mediating the phosphorylation of USP37 Thr631, and considering the results of endogenous USP37 interactomics, we preliminarily identified CDK1 as a possible mediator of USP37 Thr631 phosphorylation."
40486858