IndraLab

Statements

USP1 increases the amount of MYC. 5 / 5
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"Taken together, these results indicate that USP1 promotes the expression of c-Myc by regulating KDM4A."
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"The results revealed that USP1, but not USP1 C90S, induced c-MYC expression in a dose-dependent manner, indicating that the DUB activity of USP1 is required for c-MYC stability (Figure 5F)."
39513905
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"USP1 deubiquitinates MAX, which is an important MYC-binding protein and promotes MYC gene transcription."
40001543
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"As shown in Figure XREF_FIG, USP1 knockdown dramatically reduced levels of KDM4A and c-Myc, whereas the reconstitution of KDM4A was able to efficiently rescue their expression."
32133742
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"Furthermore, immunohistochemical analysis revealed that the expression level of c-MYC was decreased by USP1 deficiency."
39513905