IndraLab

Statements

YAP1 binds USP8. 8 / 8
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"Given the confirmed interaction between USP8 and YAP, we used rigid protein-protein docking to predict the binding sites of the interacting domains (Fig. xref )."
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"As predicted, USP8 binds to YAP through residues 956 and 969 of USP8 and residues 257 and 255 of YAP (Fig. xref )."
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"Given the established interaction between USP8 and YAP, and the observed reduction in YAP protein levels upon USP8 depletion, we hypothesized that USP8 regulates YAP protein via the ubiquitin-proteasome pathway."
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"Interestingly, YAP directly binds to the USP8 promoter region, enhancing its transcription in TNBC."
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"ChIP-qPCR confirmed that the depletion of YAP reduced the binding of YAP to the USP8 gene (Fig. xref )."
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"ChIP-qPCR experiments showed a reduced binding of YAP to the USP8 gene (Fig. xref )."
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"On the other hand, YAP could bind to the promoter region of the USP8 gene and facilitate its transcription."
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"Further endogenous co-immunoprecipitation experiments indicated that USP8 can interact with YAP in BT549 cells (Fig. xref )."
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