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USP10 activates SIRT6. 8 / 11
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"In contrast, knockdown of USP10 but not USP22 in RKO cells promoted SIRT6 degradation."
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"It was shown that knockdown of USP10 decreased Sirt6 expression , whereas overexpression of USP10 increased Sirt6 protein expression in primary cardiomyocytes after Ang II stimulation ( Figure 6C and 6D ) ."
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"Furthermore, USP10 directly regulates Sirt6 during the pathogenesis of CH."
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"For example, SIRT6 could promote EMT process in colon cancer (36), whereas SIRT6 stabilization enabled inhibition by USP10 (37)."
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"Studies have shown that the protective effect of USP10 against organ injury is related to SIRT6 ."
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"Therefore, it seems that USP10 mediated SIRT6 stabilization is largely involved in regulating c-Myc transcriptional activity."
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"The stability of Sirt6 protein was measured by using cycloheximide (CHX), and the results indicated that Sirt6 stability was enhanced by USP10 overexpression (Fig. 8C)."
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"These studies suggest the possibility that the association with RBM5-AS1 may reinforce USP10 dependent suppression of SIRT6 degradation."
| PMC